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Chlorhexidine digluconate
CAS No. 18472-51-0
Chlorhexidine digluconate( —— )
Catalog No. M33315 CAS No. 18472-51-0
Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameChlorhexidine digluconate
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NoteResearch use only, not for human use.
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Brief DescriptionChlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections.
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DescriptionChlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis.
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In VitroCell Cytotoxicity Assay Cell Line:Chinese hamster ovary cells Concentration:0.00001%, 0.00005%, 0.0001%, 0.0005% Incubation Time:1, 2, 4 h Result:Demonstrated a cytotoxic effect on CHO cells.Apoptosis Analysis Cell Line:Chinese hamster ovary cells Concentration:0.00005%, 0.0001%, 0.0005% Incubation Time:1 h Result:After a 1 hour treatment, the amount of cell apoptosis was about 1.62%, 5.51%, and 5.47%, respectively. The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively.
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In VivoModel:Male Imprinting Control Region (ICR) mice at 6 to 8-wk-old (body weight, 25g)Dosage:Chlorhexidine gluconate 0.05% and 0.025% Administration:One-time intraperitoneal injection Result:With 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | Antibiotic
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Research Area——
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Indication——
Chemical Information
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CAS Number18472-51-0
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Formula Weight897.76
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Molecular FormulaC34H54Cl2N10O14
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 100 mg/mL (111.39 mM; Ultrasonic) DMSO : ≥ 38 mg/mL (42.33 mM)
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SMILESClC(C=C1)=CC=C1NC(NC(NCCCCCCNC(NC(NC2=CC=C(C=C2)Cl)=N)=N)=N)=N.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wael E Shams, et al. Peritoneal Lavage Using Chlorhexidine Gluconate at the End of Colon Surgery Reduces Postoperative Intra-Abdominal Infection in Mice. J Surg Res. 2015 May 1;195(1):121-7.?
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