GSK778 hydrochloride( —— )

Catalog No. M37654 CAS No. 2863657-79-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK778 hydrochloride
Note

Research use only, not for human use.
Brief Description

GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.
Description

GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 hydrochloride hydrochloride phenocopies the effects of pan-BET inhibitors in cancer models.
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

Epigenetic Reader Domain
Research Area

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Indication

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CAS Number

2863657-79-6
Formula Weight

548.08
Molecular Formula

C30H34ClN5O3
Purity

>98% (HPLC)
Solubility

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SMILES

C[C@@H](N1C(COC)=NC2=C1C3=CC(OC[C@@H]4CNCC4)=C(C5=C(C)ON=C5C)C=C3N=C2)C6=CC=CC=C6.[H]Cl
Chemical Name

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