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Home - Products - Cell Cycle/DNA Damage - PARP - PARP-1-IN-4

PARP-1-IN-4

CAS No. 684234-56-8

PARP-1-IN-4( —— )

Catalog No. M37149 CAS No. 684234-56-8

PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 37 Get Quote
10MG 61 Get Quote
25MG 118 Get Quote
50MG 196 Get Quote
100MG 286 Get Quote
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Biological Information

  • Product Name
    PARP-1-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
  • Description
    PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma.
  • In Vitro
    Cell Proliferation Assay Cell Line:A549 cells Concentration:0.1, 1 and 10 μM Incubation Time:24h and 48h Result:Exhibited cytotoxicity activity against A549 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    684234-56-8
  • Formula Weight
    424.28
  • Molecular Formula
    C22H15Cl2N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 7.69 mg/mL (18.12 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C )
  • SMILES
    O=C(NC1=CC=C(Cl)C=C1)CN2N=C(C=3C=CC(Cl)=CC3)C=4C=CC=CC4C2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018;77:443-456. ?
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