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PARP-1-IN-4
CAS No. 684234-56-8
PARP-1-IN-4( —— )
Catalog No. M37149 CAS No. 684234-56-8
PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
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| 10MG | 61 | In Stock |
|
| 25MG | 122 | In Stock |
|
| 50MG | 198 | In Stock |
|
| 100MG | 296 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePARP-1-IN-4
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NoteResearch use only, not for human use.
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Brief DescriptionPARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
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DescriptionPARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma.
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In VitroCell Proliferation Assay Cell Line:A549 cells Concentration:0.1, 1 and 10 μM Incubation Time:24h and 48h Result:Exhibited cytotoxicity activity against A549 cells.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP
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Research Area——
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Indication——
Chemical Information
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CAS Number684234-56-8
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Formula Weight424.28
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Molecular FormulaC22H15Cl2N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 7.69 mg/mL (18.12 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C )
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SMILESO=C(NC1=CC=C(Cl)C=C1)CN2N=C(C=3C=CC(Cl)=CC3)C=4C=CC=CC4C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018;77:443-456. ?
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