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KSQ-4279

CAS No. 2446480-97-1

KSQ-4279( —— )

Catalog No. M35309 CAS No. 2446480-97-1

KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP, exhibiting anticancer activity. It is utilized in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine, and pancreatic cancers.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KSQ-4279
  • Note
    Research use only, not for human use.
  • Brief Description
    KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP, exhibiting anticancer activity. It is utilized in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine, and pancreatic cancers.
  • Description
    KSQ-4279 (USP1-IN-1) is a potent, first-in-class, and highly selective USP1 inhibitor. KSQ-4279 shows anticancer effects.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP | DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2446480-97-1
  • Formula Weight
    534.54
  • Molecular Formula
    C27H25F3N8O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 80 mg/mL (149.66 mM; Ultrasonic )
  • SMILES
    COc1ncnc(C2CC2)c1-c1ncc2cnn(Cc3ccc(cc3)-c3nc(cn3C(C)C)C(F)(F)F)c2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Natalie Y L Ngoi, et al. Targeting the DNA damage response beyond poly(ADP-ribose) polymerase inhibitors: novel agents and rational combinations. Curr Opin Oncol. 2022 Sep 1;34(5):559-569.?
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