KSQ-4279( —— )

Catalog No. M35309 CAS No. 2446480-97-1

KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP, exhibiting anticancer activity. It is utilized in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine, and pancreatic cancers.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	240	Get Quote
5MG	376	Get Quote
10MG	560	Get Quote
25MG	868	Get Quote
50MG	1178	Get Quote
100MG	1548	Get Quote
500MG	Get Quote	Get Quote
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Biological Information

Product Name

KSQ-4279
Note

Research use only, not for human use.
Brief Description

KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP, exhibiting anticancer activity. It is utilized in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine, and pancreatic cancers.
Description

KSQ-4279 (USP1-IN-1) is a potent, first-in-class, and highly selective USP1 inhibitor. KSQ-4279 shows anticancer effects.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

PARP
Recptor

PARP | DUB
Research Area

——
Indication

——

Chemical Information

CAS Number

2446480-97-1
Formula Weight

534.54
Molecular Formula

C27H25F3N8O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 80 mg/mL (149.66 mM; Ultrasonic )
SMILES

COc1ncnc(C2CC2)c1-c1ncc2cnn(Cc3ccc(cc3)-c3nc(cn3C(C)C)C(F)(F)F)c2n1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Natalie Y L Ngoi, et al. Targeting the DNA damage response beyond poly(ADP-ribose) polymerase inhibitors: novel agents and rational combinations. Curr Opin Oncol. 2022 Sep 1;34(5):559-569.?

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