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Topoisomerase II inhibitor 14

CAS No. 305343-00-4

Topoisomerase II inhibitor 14( —— )

Catalog No. M37019 CAS No. 305343-00-4

Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis and blocks the cell cycle in S phase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 205 In Stock
25MG 326 In Stock
50MG 421 In Stock
100MG 581 In Stock
200MG 768 In Stock
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Biological Information

  • Product Name
    Topoisomerase II inhibitor 14
  • Note
    Research use only, not for human use.
  • Brief Description
    Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis and blocks the cell cycle in S phase.
  • Description
    Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    Topoisomerase | Apoptosis | Antioxidant | NO Synthase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    305343-00-4
  • Formula Weight
    332.19
  • Molecular Formula
    C15H11Cl2N5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ClC1=C(C2N3C=4C(NC3=NC(N)=N2)=CC=CC4)C=CC(Cl)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Al-Karmalawy AA, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661.?
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