IndiMitecan

Research use only, not for human use.

IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities .

Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.

Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM.Indimitecan shows potent DNA cleavage due to Top1 inhibition.Indimitecan can be substrates for metabolic ketone reductases.Cell Proliferation Assay Cell Line:HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7Concentration:0-100 μM Incubation Time: Result:Showed growth inhibition with GI50s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM.

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Cell Cycle/DNA Damage

Topoisomerase

Topoisomerase

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915360-05-3

459.45

C25H21N3O6

>98% (HPLC)

In Vitro:?DMSO : 8.33 mg/mL (18.13 mM; Ultrasonic (<60 ℃); (HCL，pH=3)

COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCn3ccnc3)c(=O)c2cc1OC

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(-20℃)

With Ice Pack

≥ 2 years