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ND-011992

CAS No. 2446880-46-0

ND-011992( —— )

Catalog No. M36991 CAS No. 2446880-46-0

ND-011992 is a reversible and selective quinazoline inhibitor targeting quinone reductases and quinol oxidases.ND-011992 inhibits E. coli BL21*Δcyo respiratory complex I.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 105 In Stock
50MG 168 In Stock
100MG 271 In Stock
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Biological Information

  • Product Name
    ND-011992
  • Note
    Research use only, not for human use.
  • Brief Description
    ND-011992 is a reversible and selective quinazoline inhibitor targeting quinone reductases and quinol oxidases.ND-011992 inhibits E. coli BL21*Δcyo respiratory complex I.
  • Description
    ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Mitochondrial Metabolism | Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2446880-46-0
  • Formula Weight
    381.35
  • Molecular Formula
    C21H14F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C=1C2=C(N=CN1)C=CC=C2)C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. K?gi J, et al. Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. Sci Rep. 2023;13(1):12226. Published 2023 Jul 28. doi:10.1038/s41598-023-39430-w?
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