4-Hydroxybenzyl alcohol( —— )

Catalog No. M18916 CAS No. 623-05-2

4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

4-Hydroxybenzyl alcohol
Note

Research use only, not for human use.
Brief Description

4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway.
Description

4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. 4-Hydroxybenzyl alcohol inhibit the development of new blood vessels by targeting multiple mechanisms of the angiogenic process, may as a promising candidate for the establishment of anti-angiogenic treatment strategies in cancer therapy.
In Vitro

4-Hydroxybenzyl alcohol inhibits proliferation of eEND2 cells and suppresses the migration of eEND2 cells, accompanied by inhibition of actin filament reorganization.4-Hydroxybenzyl alcohol induces apoptotic death of tumor cells.
In Vivo

4-Hydroxybenzyl alcohol possesses antiangiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production. 4-Hydroxybenzyl alcohol (200 mg/kg) efficiently inhibits growth and angiogenesis of developing tumors.4-Hydroxybenzyl alcohol ameliorates ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect may be partly related to attenuate apoptosis pathway.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

——

Chemical Information

CAS Number

623-05-2
Formula Weight

124.14
Molecular Formula

C7H8O2
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL; 805.54 mM
SMILES

C1=CC(=CC=C1CO)O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Laschke MW,et al.4-hydroxybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth. 2013 Jul 19;93(1):44-50.

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