17β-HSD10-IN-1( —— )

Catalog No. M36963 CAS No. 2316765-78-1

17β-HSD10-IN-1 is an orally available 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) inhibitor with blood-brain permeability and potency for the study of Alzheimer's disease.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

17β-HSD10-IN-1
Note

Research use only, not for human use.
Brief Description

17β-HSD10-IN-1 is an orally available 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) inhibitor with blood-brain permeability and potency for the study of Alzheimer's disease.
Description

17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

Dehydrogenase | Endogenous Metabolite
Research Area

——
Indication

——

Chemical Information

CAS Number

2316765-78-1
Formula Weight

376.82
Molecular Formula

C16H13ClN4O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (66.34 mM; Ultrasonic )
SMILES

O=C(NC1=NC=2C=CC(=CC2S1)NC(=O)C)NC3=CC=C(O)C(Cl)=C3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Benek O, et al. Development of submicromolar 17尾-HSD10 inhibitors and their in vitro and in vivo evaluation. Eur J Med Chem. 2023 Oct 5;258:115593.聽?

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