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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - hDHODH-IN-5

hDHODH-IN-5

CAS No. 2029049-77-0

hDHODH-IN-5( DHODH-IN-7 )

Catalog No. M26160 CAS No. 2029049-77-0

hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    hDHODH-IN-5
  • Note
    Research use only, not for human use.
  • Brief Description
    hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase.
  • Description
    hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).(In Vitro):hDHODH-IN-5 induces differentiation in ER-HOX-GFP, THP1, and U937 human AML cell lines with EC50s of 3.6, 2.7, and 2.5 μM, respectively.
  • In Vitro
    The lysozyme-GFPER-HoxA9 murine cell line (ER-HOX-GFP) and the THP1 and U937 human AML cell lines were cultured with compounds in a 4-day differentiation assay. DHODH-IN-7 shows EC50s of 3.6, 2.7, and 2.5 μM for ER-HOX-GFP, THP1 and U937 human AML cell lines, respectively.
  • In Vivo
    ——
  • Synonyms
    DHODH-IN-7
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    p300
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2029049-77-0
  • Formula Weight
    390.406
  • Molecular Formula
    C21H21F3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)c1ccc(cc1)C(=O)NCCC(=O)N[C@@H]1CCCc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mantelingu K, et al. Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy. J Phys Chem B. 2007;111(17):4527-4534.
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