Cart
sales@molnova.com
Carotuximab
CAS No. 1268714-50-6
Carotuximab( —— )
Catalog No. M36777 CAS No. 1268714-50-6
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 376 | In Stock |
|
| 10MG | 603 | In Stock |
|
| 25MG | 934 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCarotuximab
-
NoteResearch use only, not for human use.
-
Brief DescriptionCarotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity.
-
DescriptionCarotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions.
-
In VitroWestern Blot Analysis Cell Line:Human aortic endothelial cells (HAoECs) Concentration:300 μg/mL Incubation Time:Pretreatment 1 h, and then co-cultured for 12 h Result:Reduced the 7-Ketocholesterol-induced Eng protein levels and pSmad1/5 and pSmad2/3 signaling.
-
In VivoAnimal Model:Female NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ; 7-8 weeks) injected with primary AML-0032 cells Dosage:2 mg/kg Administration:i.v; every 3 days; for 8 weeks Result:Along with Decitabine resulted in a more durable anti-leukemic effect in AML xenografts.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorTGF-beta/Smad | Immunology/Inflammation related
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1268714-50-6
-
Formula Weight
-
Molecular Formula——
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Katarina Tripska , et al. Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells. Front Med (Lausanne). 2022 Sep 7;9:845918.?
molnova catalog
related products
-
MTOB
MTOB is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.
-
Aspoxicillin
Aspoxicillin is a broad-spectrum antimicrobial agent against Actinobacillus pleuropneumoniae with of MIC90 < or = 0.05 μg/ml.
-
GSK2850163
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
