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Demcizumab

CAS No. 1243262-17-0

Demcizumab( —— )

Catalog No. M36721 CAS No. 1243262-17-0

Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Demcizumab
  • Note
    Research use only, not for human use.
  • Brief Description
    Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents.
  • Description
    Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models.
  • In Vitro
    Cell Viability AssayCell Line:PDTALL13 (patient-derived T-ALL 13) cell Concentration:0, 0.5, 1, 5, 10, 20, 40, 80 μg/mL Incubation Time:1 or 2 or 3 days Result:Dose-dependently inhibited cell viability.
  • In Vivo
    Animal Model:KRASWT and KRASMT CRC xenografts Dosage:10 mg/kg, together with Irinotecan (HY-16562) (7.5 mg/kg) Administration:Intraperitoneal injection (i.p.), once a week Result:Resulted in tumor regression at day 20.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    Gamma-secretase
  • Recptor
    Gamma-secretase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1243262-17-0
  • Formula Weight
    145.65 (kDa)
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Smith DC, et al. A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors. Clin Cancer Res. 2014 Dec 15;20(24):6295-303. ?
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