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Sifalimumab
CAS No. 1006877-41-3
Sifalimumab( —— )
Catalog No. M36703 CAS No. 1006877-41-3
Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for the treatment of moderate to severe SLE.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 739 | In Stock |
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| 10MG | 1169 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSifalimumab
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NoteResearch use only, not for human use.
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Brief DescriptionSifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for the treatment of moderate to severe SLE.
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DescriptionSifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research.
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In VitroSifalimumab (3-36 μg/well; 72 h) attenuates lymphocyte cytotoxicity co-cultured with U-87MG.Cell Viability Assay Cell Line:U-87MG cells and AGS lymphocytes Concentration:3-36 μg/well Incubation Time:72 hours Result:Attenuated lymphocyte cytotoxicity triggered by IFN I (P<0.05).
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In VivoSifalimumab (subcutaneous injection; 30 mg/kg and 3 μg/g) treatment shows therapeutic effect and attenuates the lymphocyte infiltration.Animal Model:Wild-type male BALB/c mice Dosage:30 mg/kg and 3 μg/g Administration:Subcutaneous injection; 30 mg/kg and 3 μg/g Result:Prevented the increase CpG-induced, decreasing CD86 fluorescence intensity by 1.9-fold (P < 0.05).Showed a potentially therapeutic effect attenuating the CpG-induced lymphocyte infiltration.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number1006877-41-3
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Merrill JT, et al. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon α monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis. 2011 Nov;70(11):1905-13.?
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