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Sifalimumab

CAS No. 1006877-41-3

Sifalimumab( —— )

Catalog No. M36703 CAS No. 1006877-41-3

Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for the treatment of moderate to severe SLE.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Sifalimumab
  • Note
    Research use only, not for human use.
  • Brief Description
    Sifalimumab (MEDI-545) is a monoclonal antibody that targets IFNα and suppresses abnormal immune activity by binding to interferon-alpha.Sifalimumab is used for the treatment of moderate to severe SLE.
  • Description
    Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research.
  • In Vitro
    Sifalimumab (3-36 μg/well; 72 h) attenuates lymphocyte cytotoxicity co-cultured with U-87MG.Cell Viability Assay Cell Line:U-87MG cells and AGS lymphocytes Concentration:3-36 μg/well Incubation Time:72 hours Result:Attenuated lymphocyte cytotoxicity triggered by IFN I (P<0.05).
  • In Vivo
    Sifalimumab (subcutaneous injection; 30 mg/kg and 3 μg/g) treatment shows therapeutic effect and attenuates the lymphocyte infiltration.Animal Model:Wild-type male BALB/c mice Dosage:30 mg/kg and 3 μg/g Administration:Subcutaneous injection; 30 mg/kg and 3 μg/g Result:Prevented the increase CpG-induced, decreasing CD86 fluorescence intensity by 1.9-fold (P < 0.05).Showed a potentially therapeutic effect attenuating the CpG-induced lymphocyte infiltration.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1006877-41-3
  • Formula Weight
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Merrill JT, et al. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon α monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis. 2011 Nov;70(11):1905-13.?
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