Cinchophen

Research use only, not for human use.

Cinchophen is an analgesic drug that is frequently used to treat gout.

Cinchophen is an analgesic drug that is frequently used to treat gout.(In Vivo):Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (Vd area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs.Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (Cmax) of 77.75 μg/ml and the time of Cmax (tmax) is 2.76 hours. The plasma concentration time curve (AUC0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.

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Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (Vd area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs.Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (Cmax) of 77.75 μg/ml and the time of Cmax (tmax) is 2.76 hours. The plasma concentration time curve (AUC0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.

Cinchopen | Mylofanol | Agotan | Phenophan | Tervalon | NSC2617

Chromatin/Epigenetic

COX

COX

Inflammation/Immunology

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132-60-5

249.26

C16H11NO2

>98% (HPLC)

Ethanol: 5 mg/mL (20.05 mM); DMSO: 50 mg/mL (200.59 mM)

O=C(O)C1=CC(C2=CC=CC=C2)=NC3=CC=CC=C13

2-Phenylcinchoninic acid

(-20℃)

With Ice Pack

≥ 2 years