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Chemocoxib A
CAS No. 960214-84-0
Chemocoxib A( —— )
Catalog No. M16853 CAS No. 960214-84-0
Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameChemocoxib A
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NoteResearch use only, not for human use.
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Brief DescriptionChemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.
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DescriptionChemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively; shows no signigicant activity against COX-1, and COX-2 mutant V349L, V523I, and S530A; exhibits cytotoxicity in cancer cell culture, inhibits the growth of human tumor xenografts in nude mice.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number960214-84-0
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Formula Weight924.397
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Molecular FormulaC49H50ClN3O13
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameButanoic acid, 4-[[4-[[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]butyl]amino]-4-oxo-, (5R,5aR,8aR,9R)-5,5a,6,8,8a,9-hexahydro-8-oxo-9-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-5-yl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Uddin MJ, et al. ACS Chem Biol. 2016 Nov 18;11(11):3052-3060.
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