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TGFβ1-IN-3
CAS No. 2883813-58-7
TGFβ1-IN-3( —— )
Catalog No. M36621 CAS No. 2883813-58-7
TGFβ1-IN-3, a diarylhydrazone derivative, inhibits fibroblast activation and proliferation, positioning it as a candidate compound for the treatment of idiopathic pulmonary fibrosis (IPF).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 193 | In Stock |
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| 10MG | 276 | In Stock |
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| 25MG | 430 | In Stock |
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| 50MG | 581 | In Stock |
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| 100MG | 768 | In Stock |
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| 200MG | 1032 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTGFβ1-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionTGFβ1-IN-3, a diarylhydrazone derivative, inhibits fibroblast activation and proliferation, positioning it as a candidate compound for the treatment of idiopathic pulmonary fibrosis (IPF).
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DescriptionTGFβ1-IN-3 is a diarylacylhydrazones derivative that effectively suppresses the activation and proliferation of fibroblasts. TGFβ1-IN-3 can be used for idiopathic pulmonary fibrosis (IPF) research.
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In VitroTGFβ1-IN-3 (compound 44) shows inhibitory effect against NIH-3T3 cells with an IC50 of 0.57 μM.TGFβ1-IN-3 (compound 44; 10 μM; for 24 h) inhibits TGF-β1-induced abnormal activation of NIH-3T3 and A549 cells, as well as migration and epithelial-mesenchymal transition (EMT) of A549 cells.TGFβ1-IN-3 (compound 44) could bind to STAT3, and able to interact with Ile659, and the hydrophilic group piperidine formed intermolecular forces with Ser636, Arg609, and Pro639. The nitrofuran of TGFβ1-IN-3 could interact with Lys658.Western Blot Analysis Cell Line:NIH-3T3 or A549 cells Concentration:10 μM Incubation Time:24 h Result:Were able to inhibit TGF-β1-induced activation of fibroblasts in vitro.
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In VivoTGFβ1-IN-3 (compound 44; 30-60 mg/kg; p.o; once daily; for 22 days) improves mouse lung function and slowsthe progression of IPF. TGFβ1-IN-3 could reverse the pulmonary fibrosis in treatment model. Pharmacokinetic parameters of TGFβ1-IN-3 (compound 44) in rats.Animal Model:C57BL/6 mice (6-10 weeks) injected with Bleomycin for establishing pulmonary fibrosis model.Dosage:30 mg/kg, 60 mg/kg Administration:Orally administration; once daily; for 22 days Result:Could reverse the pulmonary fibrosis in treatment model.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2883813-58-7
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Formula Weight442.51
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Molecular FormulaC23H30N4O5
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=N/NC(=O)C1=CC=C(OCCCCCCN2CCCCC2)C=C1)\C=3OC(N(=O)=O)=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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