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SMN-C2
CAS No. 1446311-56-3
SMN-C2( —— )
Catalog No. M36532 CAS No. 1446311-56-3
SMN-C2 is a selective regulator of SMN2 gene splicing, a risdiplam analogue, a selective RNA-binding ligand that regulates pre-mRNA splicing and acts by binding to SMN2 pre-mRNA.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 282 | In Stock |
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| 5MG | 264 | In Stock |
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| 10MG | 424 | In Stock |
|
| 25MG | 839 | In Stock |
|
| 50MG | 1014 | In Stock |
|
| 100MG | 1367 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSMN-C2
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NoteResearch use only, not for human use.
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Brief DescriptionSMN-C2 is a selective regulator of SMN2 gene splicing, a risdiplam analogue, a selective RNA-binding ligand that regulates pre-mRNA splicing and acts by binding to SMN2 pre-mRNA.
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DescriptionSMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number1446311-56-3
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Formula Weight417.5
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Molecular FormulaC24H27N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C(C=2N=C3N(C2)C=C(C)N=C3C)=CC=4C(O1)=CC(=CC4)N5C[C@H](C)N(CC)CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jingxin Wang, et al. Mechanistic studies of a small-molecule modulator of SMN2 splicing. Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4604-E4612.?
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