(R)-HH2853( —— )

Catalog No. M36497 CAS No. 2202678-06-4

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Product Name

(R)-HH2853
Note

Research use only, not for human use.
Brief Description

(R)-HH2853 is a potent EZH2 inhibitor with an IC50 <100 nM for EZH2-Y641F.(R)-HH2853 has anticancer and antitumor activity and can be used in autoimmune diseases.
Description

(R)-HH2853 is a mutant EZH2 inhibitor with an IC50 of <100 nM for EZH2-Y641F. (R)-HH2853 can be used for cancer and autoimmune diseases (WO2018045971A1; compound 201).
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Histone Methyltransferase
Research Area

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Indication

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CAS Number

2202678-06-4
Formula Weight

611.66
Molecular Formula

C31H36F3N7O3
Purity

>98% (HPLC)
Solubility

——
SMILES

[C@@H](C)(C=1N2C(=C(C=C2)C3=CC=C(C)N=N3)C=C(C(NCC4=C(OC)C=C(C)NC4=O)=O)C1C)N5CCN(CC(F)(F)F)CC5
Chemical Name

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1. Xuxing Chen, et al. Pyrido five-element aromatic ring compound, preparation method therefor and use thereof. WO2018045971A1.

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