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RBN-3143

CAS No. 2360853-16-1

RBN-3143( —— )

Catalog No. M36022 CAS No. 2360853-16-1

RBN-3143 is a potent inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM), which inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines, demonstrating research potential for lung inflammation.

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

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Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	145	In Stock
5MG	132	In Stock
10MG	211	In Stock
25MG	424	In Stock
50MG	621	In Stock
100MG	918	In Stock
200MG	1237	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

RBN-3143
Note

Research use only, not for human use.
Brief Description

RBN-3143 is a potent inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM), which inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines, demonstrating research potential for lung inflammation.
Description

RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation.
In Vitro

——
In Vivo

Animal Model:Mouse of asthma models Dosage:5 ug Administration:Intranasal administration Result:Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

PARP
Recptor

PARP
Research Area

——
Indication

——

Chemical Information

CAS Number

2360853-16-1
Formula Weight

449.54
Molecular Formula

C22H28FN3O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (55.61 mM; Ultrasonic (<60°C)
SMILES

CC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal?2022?60:?4642.

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