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PARP-1-IN-3
CAS No. 2976342-33-1
PARP-1-IN-3( —— )
Catalog No. M37144 CAS No. 2976342-33-1
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 37 | In Stock |
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| 5MG | 59 | In Stock |
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| 10MG | 98 | In Stock |
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| 25MG | 164 | In Stock |
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| 50MG | 240 | In Stock |
|
| 100MG | 353 | In Stock |
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| 200MG | 510 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePARP-1-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionPARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.
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DescriptionPARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer.
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In VitroApoptosis Analysis Cell Line:HCT116 cells Concentration:0.3, 1.5, 7.5 μM Incubation Time:48 and 72 h Result:Increased the percentage of total apoptotic cells from 1.05% (control group) to 79.49% (7.5 μM).Cell Cycle Analysis Cell Line:HCT116 cells Concentration:0.3, 1.5, 7.5 μM Incubation Time:48 and 72 h Result:Blocked the cell cycle progression at G2/M phase.Western Blot Analysis Cell Line:HCT116 cells Concentration:0.3, 1, 3 μM Incubation Time:48 h Result:Increased expression levels of γH2AX in a concentration-dependent manner.Western Blot Analysis Cell Line:HCT116 cells Concentration:0.3, 1, 3 μM Incubation Time:48 h Result:Increased the expression levels of Bax, cleaved Caspase-3 and cleaved-PARP, and decreased the expression level of Bcl-2.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2976342-33-1
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Formula Weight425.28
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Molecular FormulaC21H17BrN2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (293.92 mM; Ultrasonic )
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SMILESO=C(N)C=1C=CC=CC1OCC=2C=CC=C(C2)NC(=O)C3=CC=C(Br)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu G, et, al. Discovery of novel benzamide derivatives bearing benzamidophenyl and phenylacetamidophenyl scaffolds as potential antitumor agents via targeting PARP-1. Eur J Med Chem. 2023 May 5;251:115243.?
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