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PARP1/2/TNKS1/2-IN-1
CAS No. 2243453-32-7
PARP1/2/TNKS1/2-IN-1( —— )
Catalog No. M36459 CAS No. 2243453-32-7
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1, and TNKS2, with potential anti-tumor activity that induces apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 106 | Get Quote |
|
| 5MG | 159 | Get Quote |
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| 10MG | 223 | Get Quote |
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| 25MG | 263 | Get Quote |
|
| 50MG | 311 | Get Quote |
|
| 100MG | 399 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePARP1/2/TNKS1/2-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionPARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1, and TNKS2, with potential anti-tumor activity that induces apoptosis.
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DescriptionPARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP | Apoptosis | Wnt/beta-catenin
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Research Area——
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Indication——
Chemical Information
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CAS Number2243453-32-7
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Formula Weight634.66
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Molecular FormulaC35H31FN6O5
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=CC=C(NC(C2=CC=C(NC(N3CCN(CC3)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O)=O)C=C2)=O)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu Y, et al. Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy. Eur J Med Chem. 2022 Jul 5;237:114417. ?
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