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MCT1-IN-3
CAS No. 2878360-80-4
MCT1-IN-3( —— )
Catalog No. M35939 CAS No. 2878360-80-4
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 273 | In Stock |
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| 5MG | 255 | In Stock |
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| 10MG | 375 | In Stock |
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| 25MG | 562 | In Stock |
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| 50MG | 770 | In Stock |
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| 100MG | 1051 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 2111 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMCT1-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionMCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment.
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DescriptionMCT1-IN-3 is a monocarboxylate transporter 1 (MCT1)inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer.
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In VitroCell Cycle AnalysisCell Line:A-549 cells Concentration:5 μM Incubation Time:24 h Result:Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase.Apoptosis Analysis Cell Line:A-549 cells Concentration:5 μM Incubation Time:24 h Result:Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetMonocarboxylate Transporter
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RecptorMonocarboxylate transporter
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Research Area——
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Indication——
Chemical Information
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CAS Number2878360-80-4
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Formula Weight389.4
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Molecular FormulaC22H19N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=C(C(OC)=O)C#N)C=1C=2C(N(CC(NC3=CC=C(OC)C=C3)=O)C1)=CC=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sachin Puri, et al. Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1). J Med Chem. 2023 Jan 12;66(1):657-676.?
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