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MSC-4381
CAS No. 2445185-57-7
MSC-4381( —— )
Catalog No. M34984 CAS No. 2445185-57-7
MSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 176 | In Stock |
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| 5MG | 148 | In Stock |
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| 10MG | 227 | In Stock |
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| 25MG | 392 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMSC-4381
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NoteResearch use only, not for human use.
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Brief DescriptionMSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma.
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DescriptionMSC-4381 (MCT4-IN-1) is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MSC-4381 targets to the cytosolic domain of MCT4. MSC-4381 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MSC-4381 has the potential for MCT4 transporter inhibition research. MSC-4381 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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In Vitro——
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In VivoAnimal Model:MC38 tumor-bearing C57/BL6 miceDosage:30 mg/kg Administration:PO; single dose Result:Only combined with MCT1/2 inhibitor exhibited a significant tumoral intracellular lactate accumulation.Animal Model:Mice Dosage:0.2 mg/kg (Pharmacokinetic Analysis)Administration:IV Result:Had a T1/2 of 1 hours, a CL of 0.33 L/h?kg, a Cmax of 489 ng/mL and a Vss of 0.4 L/kg for mice.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetMonocarboxylate Transporter
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RecptorMonocarboxylate transporter
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Research Area——
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Indication——
Chemical Information
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CAS Number2445185-57-7
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Formula Weight537.97
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Molecular FormulaC26H20ClN3O6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (154.90 mM; Ultrasonic (<60°C)
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SMILESCCOc1ccc(c2ncccc12)S(=O)(=O)Nc1ccc(Cl)cc1C#Cc1cnc(cc1OC)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Timo Heinrich, et al. Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology. J Med Chem. 2021 Aug 26;64(16):11904-11933.?
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