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AZD0095
CAS No. 2750001-23-9
AZD0095( —— )
Catalog No. M35816 CAS No. 2750001-23-9
AZD0095 is a selective inhibitor of MCT4 with an IC50 of 1.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 282 | In Stock |
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| 5MG | 217 | In Stock |
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| 10MG | 353 | In Stock |
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| 25MG | 549 | In Stock |
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| 50MG | 775 | In Stock |
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| 100MG | 1070 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD0095
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NoteResearch use only, not for human use.
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Brief DescriptionAZD0095 is a selective inhibitor of MCT4 with an IC50 of 1.3 nM.
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DescriptionAZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205).
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In Vitro——
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In VivoAnimal Model:Murine NCI-H358 xenograft Dosage:100 mg/kg together with Cediranib (3 mg/kg) Administration:Oral administration (p.o.)Result:Reduced tumor growth more efficiently than AZD0095 or AZD2171 alone.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetMonocarboxylate Transporter
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RecptorMonocarboxylate transporter
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Research Area——
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Indication——
Chemical Information
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CAS Number2750001-23-9
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Formula Weight500.6
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Molecular FormulaC27H32N8O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (19.98 mM; Ultrasonic )
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SMILESCc1nc2nc(C)c(O[C@@H]3CCN(C3)c3ccc(cc3)-c3ccc(CN4CCOCC4)nn3)c(C)n2n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Goldberg FW, et al. Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. J Med Chem. 2022 Dec 16. ?
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