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NDI-034858
CAS No. 2272904-53-5
NDI-034858( —— )
Catalog No. M35681 CAS No. 2272904-53-5
NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 749 | In Stock |
|
| 10MG | 1197 | In Stock |
|
| 25MG | 1777 | In Stock |
|
| 50MG | 2353 | In Stock |
|
| 100MG | 3153 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNDI-034858
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NoteResearch use only, not for human use.
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Brief DescriptionNDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.
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DescriptionZasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM.
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In VitroZasocitinib (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively.Zasocitinib inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50 value of <0.1 μM in human peripheral blood mononuclear cell.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetTyrosinase
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RecptorTyrosine Kinases | IL Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2272904-53-5
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Formula Weight460.49
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Molecular FormulaC23H24N8O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (108.58 mM; Ultrasonic (<60°C)
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SMILESCNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.
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