HOIPIN-8 sodium( —— )

Catalog No. M35672 CAS No. 2519537-70-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

HOIPIN-8 sodium
Note

Research use only, not for human use.
Brief Description

HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1.
Description

HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
In Vitro

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In Vivo

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Synonyms

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Pathway

Immunology/Inflammation
Target

IκB kinase (IKK)
Recptor

IκB/IKK
Research Area

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Indication

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CAS Number

2519537-70-1
Formula Weight

456.38
Molecular Formula

C23H15F2N4NaO3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(C=C(C4=CNN=C4)C=C3F)F)=O)[O-].[Na+]
Chemical Name

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