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Home - Products - Immunology/Inflammation - IκB kinase (IKK) - BMS-345541 free base

BMS-345541 free base

CAS No. 445430-58-0

BMS-345541 free base( BMS345541 (free base) )

Catalog No. M14526 CAS No. 445430-58-0

A potent and selective IKK-2 inhibitor with IC50 of 0.3 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 91 In Stock
2MG 43 In Stock
5MG 69 In Stock
10MG 107 In Stock
25MG 217 In Stock
50MG 346 In Stock
100MG Get Quote In Stock
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Biological Information

  • Product Name
    BMS-345541 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective IKK-2 inhibitor with IC50 of 0.3 uM.
  • Description
    A potent and selective IKK-2 inhibitor with IC50 of 0.3 uM; less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε; inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM; has excellent pharmacokinetics in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BMS345541 (free base)
  • Pathway
    Immunology/Inflammation
  • Target
    IκB kinase (IKK)
  • Recptor
    IKK1|IKK2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    445430-58-0
  • Formula Weight
    255.3183
  • Molecular Formula
    C14H17N5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    Cc1ccc2c(c1)n3c(cnc3c(n2)NCCN)C
  • Chemical Name
    1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Burke JR, et al. J Biol Chem. 2003 Jan 17;278(3):1450-6. 2. McIntyre KW, et al. Arthritis Rheum. 2003 Sep;48(9):2652-9. 3. López-Guerra M, et al. Clin Cancer Res. 2009 Apr 15;15(8):2767-76.
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