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VT103
CAS No. 2290608-13-6
VT103( —— )
Catalog No. M35616 CAS No. 2290608-13-6
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 312 | In Stock |
|
| 5MG | 282 | In Stock |
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| 10MG | 447 | In Stock |
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| 25MG | 775 | In Stock |
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| 50MG | 1107 | In Stock |
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| 100MG | 1600 | In Stock |
|
| 200MG | 2167 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVT103
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NoteResearch use only, not for human use.
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Brief DescriptionVT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101.
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DescriptionVT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. VT103 can be used for the research of cancer.
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In VitroVT103 (HEK293T cells; 3 μM) appeares to be TEAD1-selective, as it does not block palmitoylation of TEAD2, TEAD3, or TEAD4. VT103 (NF2-deficient NCI-H226 cells; 3 mmol/L; 4 or 24 hours) selectively disrupts YAP–TEAD1 interaction.VT103 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1.VT103 shows an IC50 of 1.02 nM in YAP reporter assay.
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In VivoVT103 (0.3~10 mg/kg; p.o. once per day) blocks tumor growth even at 0.3 mg/kg.Animal Model:NCI-H226-tumor bearing miceDosage:0.3~10 mg/kg Administration:P.o. once per day Result:Blocked tumor growth even at 0.3 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorYAP
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Research Area——
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Indication——
Chemical Information
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CAS Number2290608-13-6
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Formula Weight410.41
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Molecular FormulaC18H17F3N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (121.83 mM; Ultrasonic )
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SMILESCNS(=O)(=O)c1ccc(Nc2ccc(cc2)C(F)(F)F)c(c1)-c1cn(C)cn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021;20(6):986-998.?
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