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Aripiprazole Lauroxil
CAS No. 1259305-29-7
Aripiprazole Lauroxil( —— )
Catalog No. M26609 CAS No. 1259305-29-7
Aripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
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| 10MG | 39 | In Stock |
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| 25MG | 63 | In Stock |
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| 50MG | 90 | In Stock |
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| 100MG | 123 | In Stock |
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| 200MG | 184 | In Stock |
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| 500MG | 311 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAripiprazole Lauroxil
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NoteResearch use only, not for human use.
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Brief DescriptionAripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic.
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DescriptionAripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic. Aripiprazole lauroxil is cleaved by esterases in vivo to N-hydroxymethyl aripiprazole (lauric acid), which is then cleaved to aripiprazole, which is non-toxic.(In Vivo):Intravenous administration of 1.87 mg/ml Aripiprazole lauroxil bioconversion in vivo involves the formation of an intermediate, N-hydroxymethyl aripiprazole. The in vitro data indicates a high bioconversion of aripiprazole lauroxil, thus, the concentration of N-hydroxymethyl aripiprazole observed in the animals dosed with aripiprazole lauroxil is surprisingly high.
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In Vitro——
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In VivoAnimal Model:Female Sprague Dawley ratsDosage:1.87?mg/ml?Administration:Blood samples is taken at 5, 15, 30?min and 1, 2, 4, 6, 8 and 24?h after administration Result:Exhibits an clearance: 0.32?±?0.11?L/h/kg.?
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Synonyms——
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorMycobacterium tuberculosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1259305-29-7
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Formula Weight660.72
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Molecular FormulaC36H51Cl2N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 8.33 mg/mL (12.61 mM)
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SMILESCCCCCCCCCCCC(=O)OCN1C(=O)CCc2ccc(OCCCCN3CCN(CC3)c3cccc(Cl)c3Cl)cc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Korycka-Machala M, et al. Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli. Molecules. 2017 Jan 17;22(1). pii: E154.
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