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Aripiprazole Lauroxil

CAS No. 1259305-29-7

Aripiprazole Lauroxil( —— )

Catalog No. M26609 CAS No. 1259305-29-7

Aripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 43 In Stock
10MG 39 In Stock
25MG 63 In Stock
50MG 90 In Stock
100MG 123 In Stock
200MG 184 In Stock
500MG 311 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Aripiprazole Lauroxil
  • Note
    Research use only, not for human use.
  • Brief Description
    Aripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic.
  • Description
    Aripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic. Aripiprazole lauroxil is cleaved by esterases in vivo to N-hydroxymethyl aripiprazole (lauric acid), which is then cleaved to aripiprazole, which is non-toxic.(In Vivo):Intravenous administration of 1.87 mg/ml Aripiprazole lauroxil bioconversion in vivo involves the formation of an intermediate, N-hydroxymethyl aripiprazole. The in vitro data indicates a high bioconversion of aripiprazole lauroxil, thus, the concentration of N-hydroxymethyl aripiprazole observed in the animals dosed with aripiprazole lauroxil is surprisingly high.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female Sprague Dawley ratsDosage:1.87?mg/ml?Administration:Blood samples is taken at 5, 15, 30?min and 1, 2, 4, 6, 8 and 24?h after administration Result:Exhibits an clearance: 0.32?±?0.11?L/h/kg.?
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Mycobacterium tuberculosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1259305-29-7
  • Formula Weight
    660.72
  • Molecular Formula
    C36H51Cl2N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 8.33 mg/mL (12.61 mM)
  • SMILES
    CCCCCCCCCCCC(=O)OCN1C(=O)CCc2ccc(OCCCCN3CCN(CC3)c3cccc(Cl)c3Cl)cc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Korycka-Machala M, et al. Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli. Molecules. 2017 Jan 17;22(1). pii: E154.
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