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GRK6-IN-2

CAS No. 2677786-27-3

GRK6-IN-2( —— )

Catalog No. M35570 CAS No. 2677786-27-3

GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GRK6-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.
  • Description
    GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    GRK (GPCRK)
  • Recptor
    GRK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2677786-27-3
  • Formula Weight
    376.43
  • Molecular Formula
    C21H21FN6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Methanol : ≥ 125 mg/mL (332.07 mM)DMSO : ≥ 100 mg/mL (265.65 mM)
  • SMILES
    CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3ccccc23)n[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147.?
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