Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - NMDAR - Lanicemine dihydrochloride

Lanicemine dihydrochloride

CAS No. 153322-06-6

Lanicemine dihydrochloride( —— )

Catalog No. M35423 CAS No. 153322-06-6

Lanicemine dihydrochloride (AZD-6765 dihydrochloride) is a low-capture NMDA channel blocker with antidepressant activity and can be used to study neurological diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 37 In Stock
2MG 29 In Stock
5MG 46 In Stock
10MG 81 In Stock
25MG 170 In Stock
50MG 276 In Stock
100MG 423 In Stock
200MG Get Quote In Stock
500MG 918 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Lanicemine dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Lanicemine dihydrochloride (AZD-6765 dihydrochloride) is a low-capture NMDA channel blocker with antidepressant activity and can be used to study neurological diseases.
  • Description
    Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley ratsDosage:3, 10 or 30?mg/kg Administration:Intraperitoneal Result:Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NMDAR
  • Recptor
    NMDAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    153322-06-6
  • Formula Weight
    271.19
  • Molecular Formula
    C13H16Cl2N2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 240 mg/mL (884.99 mM; Ultrasonic )H2O : ≥ 100 mg/mL (368.75 mM)
  • SMILES
    N[C@H](C1=CC=CC=C1)CC2=CC=CC=N2.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 5,7-Dichlorokynureni...

    5,7-Dichlorokynurenic acid is an NMDA receptor antagonist.

  • TCN213

    TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2BTCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.

  • D-AP5

    D-AP5 is a NMDA receptor antagonist.

Sign In Join Free