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D-AP5
CAS No. 79055-68-8
D-AP5( D-APV | D-2-Amino-5-phosphonovaleric acid )
Catalog No. M24788 CAS No. 79055-68-8
D-AP5 is a NMDA receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
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| 2MG | 38 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 227 | In Stock |
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| 50MG | 444 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameD-AP5
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NoteResearch use only, not for human use.
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Brief DescriptionD-AP5 is a NMDA receptor antagonist.
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DescriptionD-AP5 is a NMDA receptor antagonist. (In Vivo):D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented.D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze.
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In Vitro——
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In VivoD-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented. D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze.
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SynonymsD-APV | D-2-Amino-5-phosphonovaleric acid
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PathwayMembrane Transporter/Ion Channel
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TargetNMDAR
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RecptorNMDA
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Research Area——
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Indication——
Chemical Information
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CAS Number79055-68-8
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Formula Weight197.13
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Molecular FormulaC5H12NO5P
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Purity>98% (HPLC)
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SolubilityH2O:27.78 mg/mL (140.92 mM; Need ultrasonic); Ethanol:< 1 mg/mL (insoluble)
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SMILESC(C[C@H](C(=O)O)N)CP(=O)(O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.
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