TCN213

Research use only, not for human use.

TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2BTCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.

TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2BTCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions. Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope. TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible. In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity. In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents. Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist.

TCN 213 (30 μM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits.

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Membrane Transporter/Ion Channel

NMDAR

NMDA receptor

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556803-08-8

376.54

C18H24N4OS2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (663.94 mM)

O=C(CSc1nnc(NCc2ccccc2)s1)NCC1CCCCC1

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(-20℃)

With Ice Pack

≥ 2 years