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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - PBRM1-BD2-IN-8

PBRM1-BD2-IN-8

CAS No. 2819989-75-6

PBRM1-BD2-IN-8( —— )

Catalog No. M35350 CAS No. 2819989-75-6

PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor with PBRM1-BD2 Kd of 4.4 μM, PBRM1-BD2 IC50 of 0.16 μM, and PBRM1-BD5 Kd of 25 μM; PBRM1-BD2-IN-8 shows anti-cancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 242 In Stock
5MG 246 In Stock
10MG 357 In Stock
25MG 556 In Stock
50MG 720 In Stock
100MG 986 In Stock
200MG Get Quote In Stock
500MG 1981 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PBRM1-BD2-IN-8
  • Note
    Research use only, not for human use.
  • Brief Description
    PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor with PBRM1-BD2 Kd of 4.4 μM, PBRM1-BD2 IC50 of 0.16 μM, and PBRM1-BD5 Kd of 25 μM; PBRM1-BD2-IN-8 shows anti-cancer activity.
  • Description
    PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity.
  • In Vitro
    PBRM1-BD2-IN-8 (0-100 μM; 48 h) inhibits the growth of PBRM1-dependent prostate cancer cells.Cell Viability AssayCell Line:LNCaP cells Concentration:0-100 μM Incubation Time:48 hours Result:Inhibited the growth of LNCaP cells with IC50 value of about 9 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Epigenetic Reader Domain
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2819989-75-6
  • Formula Weight
    317.18
  • Molecular Formula
    C15H13BrN2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (315.28 mM; Ultrasonic )
  • SMILES
    O=C1C=2C(NC(N1)C3=CC(C)=CC=C3)=CC=CC2Br
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.?
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