Cart
sales@molnova.com
PBRM1-BD2-IN-8
CAS No. 2819989-75-6
PBRM1-BD2-IN-8( —— )
Catalog No. M35350 CAS No. 2819989-75-6
PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor with PBRM1-BD2 Kd of 4.4 μM, PBRM1-BD2 IC50 of 0.16 μM, and PBRM1-BD5 Kd of 25 μM; PBRM1-BD2-IN-8 shows anti-cancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 242 | In Stock |
|
| 5MG | 246 | In Stock |
|
| 10MG | 357 | In Stock |
|
| 25MG | 556 | In Stock |
|
| 50MG | 720 | In Stock |
|
| 100MG | 986 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1981 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePBRM1-BD2-IN-8
-
NoteResearch use only, not for human use.
-
Brief DescriptionPBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor with PBRM1-BD2 Kd of 4.4 μM, PBRM1-BD2 IC50 of 0.16 μM, and PBRM1-BD5 Kd of 25 μM; PBRM1-BD2-IN-8 shows anti-cancer activity.
-
DescriptionPBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity.
-
In VitroPBRM1-BD2-IN-8 (0-100 μM; 48 h) inhibits the growth of PBRM1-dependent prostate cancer cells.Cell Viability AssayCell Line:LNCaP cells Concentration:0-100 μM Incubation Time:48 hours Result:Inhibited the growth of LNCaP cells with IC50 value of about 9 μM.
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorEpigenetic Reader Domain
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2819989-75-6
-
Formula Weight317.18
-
Molecular FormulaC15H13BrN2O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (315.28 mM; Ultrasonic )
-
SMILESO=C1C=2C(NC(N1)C3=CC(C)=CC=C3)=CC=CC2Br
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.?
molnova catalog
related products
-
2-methyl-2,3,4,5-tet...
2-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one is ligand of CBP.
-
SMARCA-BD ligand 1 f...
SMARCA-BD ligand 1 for Protac is a compound that binds to SMARCA2, the BAF ATPase subunit, utilizing Protac technology to degrade SMARCA2.
-
OXFBD04
OXFBD04 is a potent and selective inhibitor of BRD4(IC50 of 166 nM).
