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PBRM1-BD2-IN-8
CAS No. 2819989-75-6
PBRM1-BD2-IN-8( —— )
Catalog No. M35350 CAS No. 2819989-75-6
PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor with PBRM1-BD2 Kd of 4.4 μM, PBRM1-BD2 IC50 of 0.16 μM, and PBRM1-BD5 Kd of 25 μM; PBRM1-BD2-IN-8 shows anti-cancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 242 | In Stock |
|
| 5MG | 246 | In Stock |
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| 10MG | 357 | In Stock |
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| 25MG | 556 | In Stock |
|
| 50MG | 720 | In Stock |
|
| 100MG | 986 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1981 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePBRM1-BD2-IN-8
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NoteResearch use only, not for human use.
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Brief DescriptionPBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor with PBRM1-BD2 Kd of 4.4 μM, PBRM1-BD2 IC50 of 0.16 μM, and PBRM1-BD5 Kd of 25 μM; PBRM1-BD2-IN-8 shows anti-cancer activity.
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DescriptionPBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity.
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In VitroPBRM1-BD2-IN-8 (0-100 μM; 48 h) inhibits the growth of PBRM1-dependent prostate cancer cells.Cell Viability AssayCell Line:LNCaP cells Concentration:0-100 μM Incubation Time:48 hours Result:Inhibited the growth of LNCaP cells with IC50 value of about 9 μM.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorEpigenetic Reader Domain
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Research Area——
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Indication——
Chemical Information
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CAS Number2819989-75-6
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Formula Weight317.18
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Molecular FormulaC15H13BrN2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (315.28 mM; Ultrasonic )
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SMILESO=C1C=2C(NC(N1)C3=CC(C)=CC=C3)=CC=CC2Br
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.?
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