IRAK4-IN-1

CAS No. 1820787-94-7

IRAK4-IN-1( —— )

Catalog No. M17387 CAS No. 1820787-94-7

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 147 In Stock
10MG 227 In Stock
25MG 464 In Stock
50MG 662 In Stock
100MG 918 In Stock
200MG Get Quote In Stock
500MG 1841 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    IRAK4-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
  • Description
    IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
  • In Vitro
    The in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB) .
  • In Vivo
    Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance(Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    IRAK-4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1820787-94-7
  • Formula Weight
    337.42
  • Molecular Formula
    C19H23N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 14.29 mg/mL 42.35 mM; H2O : < 0.1 mg/mL
  • SMILES
    N#Cc1cc2c(ncnc2N[C@@H]2CC[C@@H](N3CCOCC3)CC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.
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