Cart
sales@molnova.com
IRAK4-IN-1
CAS No. 1820787-94-7
IRAK4-IN-1( —— )
Catalog No. M17387 CAS No. 1820787-94-7
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 147 | In Stock |
|
| 10MG | 227 | In Stock |
|
| 25MG | 464 | In Stock |
|
| 50MG | 662 | In Stock |
|
| 100MG | 918 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1841 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIRAK4-IN-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionIRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
-
DescriptionIRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
-
In VitroThe in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB) .
-
In VivoOral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance(Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h.
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorIRAK-4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1820787-94-7
-
Formula Weight337.42
-
Molecular FormulaC19H23N5O
-
Purity>98% (HPLC)
-
SolubilityDMSO : 14.29 mg/mL 42.35 mM; H2O : < 0.1 mg/mL
-
SMILESN#Cc1cc2c(ncnc2N[C@@H]2CC[C@@H](N3CCOCC3)CC2)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.
molnova catalog
related products
-
SMARCA-BD ligand 1 f...
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunit SMARCA2 and is used for degrading SMARCA2 based on PROTAC.
-
CPI-203
CPI-203 is a potent BET bromodomain inhibitor with IC50 of 37 nM for BRD4.
-
PBRM1-BD2-IN-8
PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor with PBRM1-BD2 Kd of 4.4 μM, PBRM1-BD2 IC50 of 0.16 μM, and PBRM1-BD5 Kd of 25 μM; PBRM1-BD2-IN-8 shows anti-cancer activity.
