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IRAK4-IN-1

CAS No. 1820787-94-7

IRAK4-IN-1( —— )

Catalog No. M17387 CAS No. 1820787-94-7

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IRAK4-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
  • Description
    IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
  • In Vitro
    The in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB) .
  • In Vivo
    Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance(Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    IRAK-4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1820787-94-7
  • Formula Weight
    337.42
  • Molecular Formula
    C19H23N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 14.29 mg/mL 42.35 mM; H2O : < 0.1 mg/mL
  • SMILES
    N#Cc1cc2c(ncnc2N[C@@H]2CC[C@@H](N3CCOCC3)CC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.
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