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NCGC00029283
CAS No. 714240-31-0
NCGC00029283( —— )
Catalog No. M35229 CAS No. 714240-31-0
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
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| 5MG | 159 | In Stock |
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| 10MG | 259 | In Stock |
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| 25MG | 448 | In Stock |
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| 50MG | 647 | In Stock |
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| 100MG | 904 | In Stock |
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| 200MG | 1200 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNCGC00029283
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NoteResearch use only, not for human use.
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Brief DescriptionNCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM.
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DescriptionNCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively.
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In VitroNCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells.Cell Proliferation Assay Cell Line:U2-OS cells Concentration:1 μM, 10 μM, 100 μM Incubation Time:24 h, 48 h, 72 h Result:Showed a reduction in U2-OS cell proliferation.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number714240-31-0
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Formula Weight337.3
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Molecular FormulaC18H12FN3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 6.94 mg/mL (20.58 mM; Ultrasonic (<60°C)
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SMILESCOc1ccc2[nH]c(=O)c(cc2c1)-c1noc(n1)-c1ccc(F)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Bleomycin sulfate
An anticancer agent that acts by induction of DNA strand breaks; also inhibits incorporation of thymidine into DNA strands.
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HALOFUGINONE LACTATE
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM.?Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.?HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity;?this inhibition is reversed by the addition of exogenous proline or EPRS.
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Compound 3A
Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.
