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NCGC00029283

CAS No. 714240-31-0

NCGC00029283( —— )

Catalog No. M35229 CAS No. 714240-31-0

NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 169 In Stock
5MG 159 In Stock
10MG 259 In Stock
25MG 448 In Stock
50MG 647 In Stock
100MG 904 In Stock
200MG 1200 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NCGC00029283
  • Note
    Research use only, not for human use.
  • Brief Description
    NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM.
  • Description
    NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively.
  • In Vitro
    NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells.Cell Proliferation Assay Cell Line:U2-OS cells Concentration:1 μM, 10 μM, 100 μM Incubation Time:24 h, 48 h, 72 h Result:Showed a reduction in U2-OS cell proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    714240-31-0
  • Formula Weight
    337.3
  • Molecular Formula
    C18H12FN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.94 mg/mL (20.58 mM; Ultrasonic (<60°C)
  • SMILES
    COc1ccc2[nH]c(=O)c(cc2c1)-c1noc(n1)-c1ccc(F)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.?
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