Carmofur( HCFU )

Catalog No. M15315 CAS No. 61422-45-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Carmofur
Note

Research use only, not for human use.
Brief Description

Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal Y.
Description

Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal Y. Carmofur has been known to induce leukoencephalopathy.
In Vitro

Real Time qPCR Cell Line:Raw264.7 Concentration:10 μM. After LPS treatment (500 ng/mL; 72 h)Incubation Time:30 min Result:Effectively reduced the mRNA expression of pro-inflammatory cytokines such as IL-1β, IL-6, iNOS, TNF-α.Western Blot Analysis Cell Line:Raw264.7 Concentration:1 μM, 3 μM, 10 μM. After LPS treatment (500 ng/mL; 72 h) Incubation Time:30 min Result:Down-regulated the expression levels of p-p65 and p-κbα proteins in a dose-dependent manner, blocking the nuclear translocation of p65.
In Vivo

Animal Model:Male C57BL/6J mice model of LPS-induced ALI Dosage:3 mg/kg, 10 mg/kg Administration:Oral gavage (p.o.), single dose. After LPS treatment (5 mg/kg; Tracheal perfusion, single dose)Result:Significantly inhibited MPO activity, which is a marker of neutrophil abundance.Alleviated alveolar edema and inhibited neutrophil accumulation.
Synonyms

HCFU
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis
Research Area

Cancer
Indication

——

CAS Number

61422-45-5
Formula Weight

257.27
Molecular Formula

C11H16FN3O3
Purity

>98% (HPLC)
Solubility

Ethanol: 10 mg/mL (38.87 mM); DMSO: 52 mg/mL (202.13 mM)
SMILES

O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC
Chemical Name

5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide

1.Miyazaki N, Tabata Y. J Nanosci Nanotechnol. 2009 Aug; 9(8):4797-804.

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