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(E/Z)-E64FC26

CAS No. 2285446-67-3

(E/Z)-E64FC26( —— )

Catalog No. M35160 CAS No. 2285446-67-3

(E/Z)-E64FC26 is a potent protein disulfide isomerase (PDI) family inhibitor with potential antitumor activity and affinity for PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6. (E/Z)-E64FC26 can be used for myeloma research.

Purity : >98% (HPLC)

COA

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HNMR

HPLC

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Biological Information

Product Name

(E/Z)-E64FC26
Note

Research use only, not for human use.
Brief Description

(E/Z)-E64FC26 is a potent protein disulfide isomerase (PDI) family inhibitor with potential antitumor activity and affinity for PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6. (E/Z)-E64FC26 can be used for myeloma research.
Description

(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

——
Indication

——

Chemical Information

CAS Number

2285446-67-3
Formula Weight

340.38
Molecular Formula

C19H23F3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (293.79 mM; Ultrasonic )
SMILES

FC(F)(F)C1=CC(=CCCCCCCCC)C=2C=C(O)C(O)=CC21
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1.

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