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Cremophor EL
CAS No. 61791-12-6
Cremophor EL( —— )
Catalog No. M35117 CAS No. 61791-12-6
Cremophor EL is a nonionic surfactant. cremophor EL inhibits cellular metabolism and suppresses UGT1A1-mediated rhodopsin glucuronidation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCremophor EL
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NoteResearch use only, not for human use.
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Brief DescriptionCremophor EL is a nonionic surfactant. cremophor EL inhibits cellular metabolism and suppresses UGT1A1-mediated rhodopsin glucuronidation.
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DescriptionCremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of agents.
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In VitroCremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorUGT
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Research Area——
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Indication——
Chemical Information
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CAS Number61791-12-6
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Formula Weight172.01
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Molecular FormulaC4H7Cl2NO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Ethanol : 50 mg/mL (Ultrasonic)H2O : 25 mg/mL (Ultrasonic)
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kiss L, et al. Kinetic analysis of the toxicity of pharmaceutical excipients Cremophor EL and RH40 on endothelial and epithelial cells. J Pharm Sci. 2013 Apr;102(4):1173-81.?
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