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7-(Diethylamino)coumarin-3-carboxylic acid
7-(Diethylamino)coumarin-3-carboxylic acid
CAS No. 50995-74-9
7-(Diethylamino)coumarin-3-carboxylic acid( DEAC | Coumarin D 1421 | D 1421 )
Catalog No. M20458 CAS No. 50995-74-9
7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | 27 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name7-(Diethylamino)coumarin-3-carboxylic acid
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NoteResearch use only, not for human use.
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Brief Description7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.
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Description7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.
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In Vitro——
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In Vivo——
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SynonymsDEAC | Coumarin D 1421 | D 1421
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PathwayMembrane Transporter/Ion Channel
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TargetMonocarboxylate Transporter
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RecptorMCT1
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Research Area——
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Indication——
Chemical Information
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CAS Number50995-74-9
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Formula Weight261.27
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Molecular FormulaC14H15NO4
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Purity>98% (HPLC)
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SolubilityDMSO:32 mg/mL (122.48 mM)
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SMILESCCN(CC)c1ccc2cc(C(O)=O)c(=O)oc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Draoui N Schicke O Seront E et al. Antitumor Activity of 7-Aminocarboxycoumarin Derivatives a New Class of Potent Inhibitors of Lactate Influx but Not Efflux[J]. Molecular Cancer Therapeutics 2014 13(6):1410-1418.
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