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SSK1
CAS No. 2629250-69-5
SSK1( —— )
Catalog No. M34948 CAS No. 2629250-69-5
SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 464 | In Stock |
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| 5MG | 353 | In Stock |
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| 10MG | 534 | In Stock |
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| 25MG | 848 | In Stock |
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| 50MG | 1144 | In Stock |
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| 100MG | 1609 | In Stock |
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| 200MG | 2167 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSSK1
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NoteResearch use only, not for human use.
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Brief DescriptionSSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.
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DescriptionSSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis.
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In VitroCell Proliferation Assay Cell Line:Primary mouse fibroblasts,Concentration:0.5?μM,Incubation Time:12 hours, 24 hours, 36 hours, 48 hours, 72 hours Result:Both p38 MAPK and MKK3/MKK6 were activated by phosphorylation in senescent cells.
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In VivoAnimal Model:Mice (3-6-month-old) were subjected to transtracheal injection of Bleomycin Dosage:0.5 mg/kg Administration:Intraperitoneally injection; two days every week; for four weeks Result:SSK1 significantly reduced the percentage of SA-β-gal-positive cells in lung by 3.8-fold compared with t hat in vehicle-treated lung-injured mice
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number2629250-69-5
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Formula Weight788.61
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Molecular FormulaC31H34F2N4O18
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (253.61 mM; Ultrasonic )
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SMILES[H][C@]1(O[C@H](CO)[C@@H](O)C1(F)F)n1ccc(NC(=O)OCc2ccc(O[C@@H]3O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)c(c2)[N+]([O-])=O)nc1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yusheng Cai, et al. Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res. 2020 Jul;30(7):574-589.?
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