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Tetrac
CAS No. 67-30-1
Tetrac( —— )
Catalog No. M34879 CAS No. 67-30-1
Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 10MG | 37 | In Stock |
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| 25MG | 75 | In Stock |
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| 50MG | 110 | In Stock |
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| 100MG | 161 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 407 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTetrac
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NoteResearch use only, not for human use.
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Brief DescriptionTetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.
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DescriptionTetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities.
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In VitroTetrac (0.01-1 μM; 2-6 d) induces anti-proliferation in HT-29 and HCT116 cells with different K-RAS status.Tetrac (0.1 μM; 30 min) inhibits activation of ERK1/2 in HT-29 and HCT116 cells.Tetrac (0.1 μM; 24 h) inhibits expression of CCND1 and c-Myc, but promotes expression of CASP2 and THBS1.Cell Proliferation Assay Cell Line:HT-29 and HCT116 cells Concentration:0.01, 0.1, 1 μM Incubation Time:0, 2, 4, 6 days Result:Induced anti-proliferation of K-RAS wild-type colorectal cancer cells.Western Blot Analysis Cell Line:HT-29 and HCT116 cells Concentration:0.1 μM Incubation Time:30 min Result:Inhibited constitutively activated ERK1/2, and this inhibition can remove by anti-integrin αvβ3 antibody pretreatment.
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In VivoTetrac (35 μg; p.o. for 40 days) inhibits tumor inoculation, growth and integrin expression in mice.Animal Model:Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells Dosage:35 μg per day Administration:P.o. (added to the drinking water) daily for 40 days Result:Delayed the onset of ocular melanoma.Reduced the S-100 and integrin staining level in the B16F10 mice model.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | EGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number67-30-1
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Formula Weight747.83
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Molecular FormulaC14H8I4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (133.72 mM; Ultrasonic )
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SMILESOC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Clitocine
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