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Rigosertib
CAS No. 592542-59-1
Rigosertib( ON-01910 )
Catalog No. M24584 CAS No. 592542-59-1
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 52 | In Stock |
|
| 10MG | 92 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRigosertib
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NoteResearch use only, not for human use.
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Brief DescriptionRigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM).
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DescriptionRigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kinase/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in the cell cycle.
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In Vitro——
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In Vivo——
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SynonymsON-01910
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis|BCR-ABL|Cdk1|Flt1|Fyn|PDGFR|PLK1|PLK2|Src
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Research Area——
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Indication——
Chemical Information
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CAS Number592542-59-1
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Formula Weight451.49
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Molecular FormulaC21H25NO8S
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Purity>98% (HPLC)
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SolubilityDMSO:75 mg/mL (166.12 mM; Need ultrasonic)
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SMILESCOC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Galgravin
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protect against neuronal death from 1-methyl-4-phenylpyridinium ion (MPP+)-induced toxicity in cultured rat hippocampal neurons.
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Pitstop 2
Pitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.
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Geranylgeraniol
Geranylgeraniol is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol protects monocytes against statin-induced cytotoxicity and suppresses the growth of Mycobacterium.
