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Rigosertib
CAS No. 592542-59-1
Rigosertib( ON-01910 )
Catalog No. M24584 CAS No. 592542-59-1
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 92 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRigosertib
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NoteResearch use only, not for human use.
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Brief DescriptionRigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM).
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DescriptionRigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kinase/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in the cell cycle.
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In Vitro——
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In Vivo——
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SynonymsON-01910
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis|BCR-ABL|Cdk1|Flt1|Fyn|PDGFR|PLK1|PLK2|Src
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Research Area——
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Indication——
Chemical Information
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CAS Number592542-59-1
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Formula Weight451.49
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Molecular FormulaC21H25NO8S
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Purity>98% (HPLC)
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SolubilityDMSO:75 mg/mL (166.12 mM; Need ultrasonic)
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SMILESCOC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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β-Elemene
β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro.?Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition.?
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Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections.
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N-Hexanoyl-D-sphingo...
C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects.
