Rigosertib

CAS No. 592542-59-1

Rigosertib( ON-01910 )

Catalog No. M24584 CAS No. 592542-59-1

Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 32 In Stock
5MG 52 In Stock
10MG 92 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Rigosertib
  • Note
    Research use only, not for human use.
  • Brief Description
    Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM).
  • Description
    Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kinase/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in the cell cycle.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ON-01910
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|BCR-ABL|Cdk1|Flt1|Fyn|PDGFR|PLK1|PLK2|Src
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    592542-59-1
  • Formula Weight
    451.49
  • Molecular Formula
    C21H25NO8S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:75 mg/mL (166.12 mM; Need ultrasonic)
  • SMILES
    COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xu F, et al. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signalingtransduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310.
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