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Rp-cAMPS sodium

CAS No. 142439-94-9

Rp-cAMPS sodium( —— )

Catalog No. M34873 CAS No. 142439-94-9

Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a protein kinase A inhibitor and a membrane-permeable cAMP antagonist that inhibits cAMP-dependent protein kinases by blocking cAMP-induced conformational transitions, and can be used in the study of cardiovascular diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rp-cAMPS sodium
  • Note
    Research use only, not for human use.
  • Brief Description
    Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a protein kinase A inhibitor and a membrane-permeable cAMP antagonist that inhibits cAMP-dependent protein kinases by blocking cAMP-induced conformational transitions, and can be used in the study of cardiovascular diseases.
  • Description
    Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    PKA
  • Recptor
    PKA | cAMP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    142439-94-9
  • Formula Weight
    367.25
  • Molecular Formula
    C10H11N5NaO5PS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 250 mg/mL (680.74 mM; Ultrasonic)
  • SMILES
    O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])OP([S-])(OC2)=O)N3C4=NC=NC(N)=C4N=C3.[Na+]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142(2):255-60.?
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