Cart
sales@molnova.com
Mitoguazone
CAS No. 459-86-9
Mitoguazone( —— )
Catalog No. M34774 CAS No. 459-86-9
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 113 | In Stock |
|
| 10MG | 169 | In Stock |
|
| 25MG | 307 | In Stock |
|
| 50MG | 457 | In Stock |
|
| 100MG | 641 | In Stock |
|
| 200MG | 905 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMitoguazone
-
NoteResearch use only, not for human use.
-
Brief DescriptionMitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis.
-
DescriptionMitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | HIV Protease
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number459-86-9
-
Formula Weight184.2
-
Molecular FormulaC5H12N8
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?H2O : 50 mg/mL (271.44 mM; ultrasonic and adjust pH to 9 with HCl)DMSO : 8.33 mg/mL (45.22 mM; Ultrasonic (<60°C)
-
SMILESC\C(\C=N\NC(N)=N)=N/NC(N)=N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. J Rizzo, et al. Pharmacokinetic Profile of Mitoguazone (MGBG) in Patients With AIDS Related non-Hodgkin's Lymphoma. Invest New Drugs. 1996;14(2):227-34.?
molnova catalog
related products
-
TAS6417
TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC.
-
Lonicerin
Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
-
N-Hexanoyl-D-sphingo...
C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects.
