Cart
sales@molnova.com
AOH1996
CAS No. 2089314-64-5
AOH1996( —— )
Catalog No. M36932 CAS No. 2089314-64-5
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 140 | In Stock |
|
| 10MG | 217 | In Stock |
|
| 25MG | 440 | In Stock |
|
| 50MG | 644 | In Stock |
|
| 100MG | 917 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1832 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAOH1996
-
NoteResearch use only, not for human use.
-
Brief DescriptionAOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).
-
DescriptionAOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | DNA
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2089314-64-5
-
Formula Weight426.46
-
Molecular FormulaC26H22N2O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
PHYTOSPHINGOSINE
Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.
-
Hirsutine
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.
-
TJ08
TJ08 is a 1,2,5-trisubstituted benzimidazole derivative with anticancer properties that effectively induces G1/S phase blockade while promoting apoptotic effects in a variety of cancer cells.
