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AOH1996

CAS No. 2089314-64-5

AOH1996( —— )

Catalog No. M36932 CAS No. 2089314-64-5

AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	217	In Stock
25MG	440	In Stock
50MG	644	In Stock
100MG	917	In Stock
200MG	Get Quote	In Stock
500MG	1832	In Stock
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Biological Information

Product Name

AOH1996
Note

Research use only, not for human use.
Brief Description

AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).
Description

AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis | DNA
Research Area

——
Indication

——

Chemical Information

CAS Number

2089314-64-5
Formula Weight

426.46
Molecular Formula

C26H22N2O4
Purity

>98% (HPLC)
Solubility

——
SMILES

C(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

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