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Bictegravir Sodium
CAS No. 1807988-02-8
Bictegravir Sodium( —— )
Catalog No. M34752 CAS No. 1807988-02-8
Bictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 28 | In Stock |
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| 5MG | 35 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 113 | In Stock |
|
| 50MG | 213 | In Stock |
|
| 100MG | 317 | In Stock |
|
| 200MG | 454 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBictegravir Sodium
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NoteResearch use only, not for human use.
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Brief DescriptionBictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity
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DescriptionBictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity.
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In VitroBictegravir sodium potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC50]/EC50) of ～6,800 in MT-2 cells and ～1,500 in MT-4 cells.
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number1807988-02-8
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Formula Weight471.36
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Molecular FormulaC21H17F3N3NaO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 16.67 mg/mL (35.37 mM; Ultrasonic (<60°C)
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SMILESO=C(C([O-])=C1C2=O)C(C(NCC3=C(F)C=C(F)C=C3F)=O)=CN1C[C@@H](O4)N2[C@@H]5C[C@H]4CC5.[Na+]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tsiang M, et al. Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097.?
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