Selatinib( —— )

Catalog No. M34707 CAS No. 1275595-86-2

Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.

Purity : >98% (HPLC)

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Biological Information

Product Name

Selatinib
Note

Research use only, not for human use.
Brief Description

Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.
Description

Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

——
Indication

——

Chemical Information

CAS Number

1275595-86-2
Formula Weight

565.06
Molecular Formula

C29H26ClFN4O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (176.97 mM; Ultrasonic )
SMILES

CS(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Meng-Na Wang, et al. First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects. Invest New Drugs. 2020 Dec;38(6):1826-1835.?

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