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SU5402
CAS No. 215543-92-3
SU5402( SU5402 | SU-5402 | SU 5402 )
Catalog No. M17435 CAS No. 215543-92-3
SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
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| 5MG | 56 | In Stock |
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| 10MG | 86 | In Stock |
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| 25MG | 161 | In Stock |
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| 50MG | 262 | In Stock |
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| 100MG | 368 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSU5402
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NoteResearch use only, not for human use.
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Brief DescriptionSU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
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DescriptionSU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively).
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In Vitro——
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In Vivo——
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SynonymsSU5402 | SU-5402 | SU 5402
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PathwayAngiogenesis
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TargetEGFR
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RecptorFGFR1| PDGFRβ| VEGFR2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number215543-92-3
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Formula Weight296.32
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Molecular FormulaC17H16N2O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 30 mg/mL; 101.24 mM
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SMILESCC1=CNC(=C1CCC(=O)O)/C=C\2/C3=CC=CC=C3NC2=O
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Chemical Name(Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid.
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Vandetanib
Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability.
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EGFR-IN-1 hydrochlor...
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR, with 100-fold selectivity over wild-type EGFR.
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EGFR-IN-7
EGFR-IN-7 is a selective and potent EGFR kinase inhibitor.TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib.
