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PF 6274484
CAS No. 1035638-91-5
PF 6274484( —— )
Catalog No. M23243 CAS No. 1035638-91-5
PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 58 | In Stock |
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| 2MG | 32 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 343 | In Stock |
|
| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1107 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF 6274484
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NoteResearch use only, not for human use.
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Brief DescriptionPF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM.
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DescriptionPF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number1035638-91-5
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Formula Weight372.8
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Molecular FormulaC18H14ClFN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (67.06 mM)
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SMILESCOc(cc(c1c2)ncnc1Nc(cc1)cc(Cl)c1F)c2NC(C=C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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