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PF 6274484

CAS No. 1035638-91-5

PF 6274484( —— )

Catalog No. M23243 CAS No. 1035638-91-5

PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 31 In Stock
5MG 50 In Stock
10MG 84 In Stock
25MG 177 In Stock
50MG 332 In Stock
100MG 494 In Stock
500MG 1071 In Stock
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Biological Information

  • Product Name
    PF 6274484
  • Note
    Research use only, not for human use.
  • Brief Description
    PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM.
  • Description
    PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1035638-91-5
  • Formula Weight
    372.8
  • Molecular Formula
    C18H14ClFN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (67.06 mM)
  • SMILES
    COc(cc(c1c2)ncnc1Nc(cc1)cc(Cl)c1F)c2NC(C=C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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