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PF 6274484

CAS No. 1035638-91-5

PF 6274484( —— )

Catalog No. M23243 CAS No. 1035638-91-5

PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 58 In Stock
2MG 32 In Stock
5MG 52 In Stock
10MG 88 In Stock
25MG 187 In Stock
50MG 343 In Stock
100MG 511 In Stock
200MG Get Quote In Stock
500MG 1107 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PF 6274484
  • Note
    Research use only, not for human use.
  • Brief Description
    PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM.
  • Description
    PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1035638-91-5
  • Formula Weight
    372.8
  • Molecular Formula
    C18H14ClFN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (67.06 mM)
  • SMILES
    COc(cc(c1c2)ncnc1Nc(cc1)cc(Cl)c1F)c2NC(C=C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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